Enhanced anticancer potency of hydroxytyrosol and curcumin by <scp>PLGA‐PAA nano‐encapsulation</scp> on <scp>PANC</scp> ‐1 pancreatic cancer cell line
نویسندگان
چکیده
Many chemotherapeutic regimens have been investigated for advanced unresectable and metastatic pancreatic cancer (PC), but with only minimal improvement in survival prognosis. Here, we anti-cancer function of free nano-encapsulated hydroxytyrosol (Hyd) curcumin (Cur), its combinations (Hyd-Cur) on PANC-1 cell line. The poly lactide-co-glycolide-co-polyacrylic acid (PLGA-co-PAA) Hyd Cur were synthesized, MTT assay was performed to evaluate cytotoxic effects Hyd, Cur, Hyd-Cur. Effects Hyd-Cur evaluated viability, migration, morphological alterations, colony formation, apoptosis cells. We observed that significantly increased rates as well decreased formation According our results, combination nano-encapsulation therapy exerts more profound apoptotic anti-proliferative cells than or monotherapy.
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ژورنال
عنوان ژورنال: Environmental Toxicology
سال: 2021
ISSN: ['1520-4081', '1522-7278']
DOI: https://doi.org/10.1002/tox.23103